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Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Bratkowski, Matthew; Burdett, Thomas C; Danao, Jean; Wang, Xidao; Mathur, Prakhyat; Gu, Weijing; Beckstead, Jennifer A; Talreja, Santosh; Yang, Yu-San; Danko, Gregory; Park, Jae Hong; Walton, Mary; Brown, Sean P; Tegley, Christopher M; Joseph, Prem Raj B; Reynolds, Charles H; Sambashivan, Shilpa.
Afiliação
  • Bratkowski M; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Burdett TC; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Danao J; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Wang X; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Mathur P; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Gu W; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Beckstead JA; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Talreja S; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Yang YS; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Danko G; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Park JH; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Walton M; Chemistry Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Brown SP; Chemistry Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Tegley CM; Chemistry Department, Nura Bio Inc., South San Francisco, CA 94080, USA.
  • Joseph PRB; WuXi AppTec, Research Services Division, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA.
  • Reynolds CH; Gfree Bio, 10601 FM 2222 Ste R PMB 206, Austin, TX 78730, USA.
  • Sambashivan S; Biology Department, Nura Bio Inc., South San Francisco, CA 94080, USA. Electronic address: ssambashivan@nurabio.com.
Neuron ; 110(22): 3711-3726.e16, 2022 11 16.
Article em En | MEDLINE | ID: mdl-36087583
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Domínio Armadillo / NAD Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Domínio Armadillo / NAD Idioma: En Ano de publicação: 2022 Tipo de documento: Article