Lysine acetylome profiling in mouse hippocampus and its alterations upon FMRP deficiency linked to abnormal energy metabolism.

Wu, Yue-Ying; Yang, Cui; Yan, Hua-Juan; Lu, Ping; Zhang, Li; Feng, Weng-Cai; Long, Yue-Sheng

Wu, Yue-Ying; Yang, Cui; Yan, Hua-Juan; Lu, Ping; Zhang, Li; Feng, Weng-Cai; Long, Yue-Sheng.

Afiliação

Wu YY; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Yang C; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Yan HJ; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Lu P; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Zhang L; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Feng WC; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Long YS; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. Electronic address: longyuesheng@gzhmu.edu.cn

J Proteomics ; 269: 104720, 2022 10 30.

Article em En | MEDLINE | ID: mdl-36089189

Assuntos

Transtorno do Espectro Autista; Síndrome do Cromossomo X Frágil; Deficiência Intelectual; Trifosfato de Adenosina/metabolismo; Animais; Ácidos Carboxílicos; Cromatografia Líquida; Citratos; Modelos Animais de Doenças; Metabolismo Energético; Proteína do X Frágil da Deficiência Intelectual/genética; Proteína do X Frágil da Deficiência Intelectual/metabolismo; Síndrome do Cromossomo X Frágil/genética; Síndrome do Cromossomo X Frágil/metabolismo; Síndrome do Cromossomo X Frágil/patologia; Hipocampo/metabolismo; Lactatos; Lisina/metabolismo; Camundongos; Camundongos Knockout; Proteômica; Espectrometria de Massas em Tandem

Palavras-chave

Energy metabolism; FMRP; Hippocampus; Lysine acetylome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista / Síndrome do Cromossomo X Frágil / Deficiência Intelectual Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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