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Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.
Wu, Yan; Liu, Yue-Yang; Liu, Hong-Kun; Yu, Shang-Bo; Lin, Furong; Zhou, Wei; Wang, Hui; Zhang, Dan-Wei; Li, Zhan-Ting; Ma, Da.
Afiliação
  • Wu Y; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Liu YY; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Liu HK; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Yu SB; Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China.
  • Lin F; Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China.
  • Zhou W; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Wang H; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Zhang DW; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Li ZT; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
  • Ma D; School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University 1139 Shifu Avenue, Jiaojiang Zhejiang 318000 China dama@fudan.edu.cn.
Chem Sci ; 13(32): 9243-9248, 2022 Aug 17.
Article em En | MEDLINE | ID: mdl-36093029
Supramolecular sequestration and reversal of neuromuscular block (NMB) have great clinical applications. Water-soluble flexible organic frameworks (FOFs) cross-linked by disulfide bonds are designed and prepared. Different linker lengths are introduced to FOFs to give them varied pore sizes. FOFs are anionic nanoscale polymers and capable of encapsulating cationic neuromuscular blocking agents (NMBAs), including rocuronium (Roc), vecuronium (Vec), pancuronium (Panc) and cisatracurium (Cis). A host-guest study confirms that FOFs bind NMBAs in water. The multivalency interaction between FOFs and NMBAs is able to sequester NMBAs, and prevent them from escaping. These FOFs are non-toxic and biocompatible. Animal studies show that FOFs are effective for the reversal of NMB induced by Roc, Vec and Cis, which shorten the time to a train-of-four ratio of 0.9 by 2.6, 3.8 and 5.7-fold compared to a placebo, respectively.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article