Investigation of the risk factors to predict cytokine release syndrome in relapsed or refractory B-cell acute lymphoblastic leukemia patients receiving IL-6 knocking down anti-CD19 chimeric antigen receptor T-cell therapy.

Gong, Wen-Jie; Qiu, Yan; Li, Ming-Hao; Chen, Li-Yun; Li, Yan-Yan; Yu, Jing-Qiu; Kang, Li-Qing; Sun, Ai-Ning; Wu, De-Pei; Yu, Lei; Xue, Sheng-Li

Gong, Wen-Jie; Qiu, Yan; Li, Ming-Hao; Chen, Li-Yun; Li, Yan-Yan; Yu, Jing-Qiu; Kang, Li-Qing; Sun, Ai-Ning; Wu, De-Pei; Yu, Lei; Xue, Sheng-Li.

Afiliação

Gong WJ; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qiu Y; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Li MH; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chen LY; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Li YY; Research and Development Department, Shanghai UnicarTherapy Bio-Medicine Technology Co., Ltd., Shanghai, China.
Yu JQ; Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Kang LQ; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Sun AN; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Wu DP; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yu L; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Xue SL; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Front Immunol ; 13: 922212, 2022.

Article em En | MEDLINE | ID: mdl-36105799

Assuntos

Linfoma Folicular; Leucemia-Linfoma Linfoblástico de Células Precursoras; Receptores de Antígenos Quiméricos; Proteínas Adaptadoras de Transdução de Sinal; Antígenos CD19; Terapia Baseada em Transplante de Células e Tecidos; Síndrome da Liberação de Citocina/etiologia; Humanos; Interleucina-6/genética; Linfoma Folicular/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia; Receptores de Antígenos Quiméricos/genética; Receptores de Antígenos Quiméricos/uso terapêutico; Fatores de Risco

Palavras-chave

IL-6 knocking down; chimeric antigen receptor T-cell therapy; cytokine release syndrome; relapsed or refractory B-cell acute lymphoblastic leukemia; risk factors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Folicular / Leucemia-Linfoma Linfoblástico de Células Precursoras / Receptores de Antígenos Quiméricos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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