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Sublethal ammonia induces alterations of emotions, cognition, and social behaviors in zebrafish (Danio rerio).
Lin, Li-Yih; Horng, Jiun-Lin; Cheng, Chieh-An; Chang, Chun-Yung; Cherng, Bor-Wei; Liu, Sian-Tai; Chou, Ming-Yi.
Afiliação
  • Lin LY; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
  • Horng JL; Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan.
  • Cheng CA; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
  • Chang CY; Department of Life Science, National Taiwan University, Taipei 10617, Taiwan.
  • Cherng BW; Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan.
  • Liu ST; Department of Life Science, National Taiwan University, Taipei 10617, Taiwan.
  • Chou MY; Department of Life Science, National Taiwan University, Taipei 10617, Taiwan. Electronic address: mingyichou@ntu.edu.tw.
Ecotoxicol Environ Saf ; 244: 114058, 2022 Oct 01.
Article em En | MEDLINE | ID: mdl-36108432
Ammonia pollutants were usually found in aquatic environments is due to urban sewage, industrial wastewater discharge, and agricultural runoff and concentrations as high as 180 mg/L (NH4+) have been reported in rivers. High ammonia levels are known to impair multiple tissue and cell functions and cause fish death. Although ammonia is a potent neurotoxin, how sublethal concentrations of ammonia influence the central nervous system (CNS) and the complex behaviors of fish is still unclear. In the present study, we demonstrated that acute sublethal ammonia exposure can change social behavior of adult zebrafish. The exposure to 90 mg /L of (NH4+) for 4 h induced a strong fear response and lower shoaling cohesion; exposure to 180 mg /L of (NH4+) for 4 h reduced the aggressiveness, and social recognition, while the anxiety, social preference, learning, and short-term memory were not affected. Messenger RNA expressions of glutaminase and glutamate dehydrogenase in the brain were induced, suggesting that ammonia exposure altered glutamate neurotransmitters in the CNS. Our findings in zebrafish provided delicate information of ammonia neurotoxicity in complex higher-order social behaviors, which has not been revealed previously. In conclusion, sublethal and acute ammonia exposure can change specific behaviors of fish, which might lead to reductions in individual and population fitness levels.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Peixe-Zebra Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Peixe-Zebra Idioma: En Ano de publicação: 2022 Tipo de documento: Article