The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats.
Life Sci
; 308: 120959, 2022 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-36108768
ABSTRACT
AIM:
To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats.METHODS:
Male rats (12 months old) were divided into three groups Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. KEYFINDINGS:
HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT.SIGNIFICANCE:
The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Treinamento Intervalado de Alta Intensidade
/
Hipertensão
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article