A simulation of parental and glycolytic tumor phenotype competition predicts observed responses to pH changes and increased glycolysis after anti-VEGF therapy.

Rentzeperis, Frederika; Miller, Naomi; Ibrahim-Hashim, Arig; Gillies, Robert J; Gatenby, Robert A; Wallace, Dorothy

Rentzeperis, Frederika; Miller, Naomi; Ibrahim-Hashim, Arig; Gillies, Robert J; Gatenby, Robert A; Wallace, Dorothy.

Afiliação

Rentzeperis F; Department of Mathematics, Dartmouth College, 1145 Hinman, Hanover, 03755-3551, NH, USA. Electronic address: frederika.rentzeperis@icahn.mssm.edu.
Miller N; Department of Mathematics, Dartmouth College, 1145 Hinman, Hanover, 03755-3551, NH, USA.
Ibrahim-Hashim A; Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Gillies RJ; Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Gatenby RA; Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Wallace D; Department of Mathematics, Dartmouth College, 1145 Hinman, Hanover, 03755-3551, NH, USA. Electronic address: Dorothy.I.Wallace@Dartmouth.edu.

Math Biosci ; 352: 108909, 2022 10.

Article em En | MEDLINE | ID: mdl-36108797

Assuntos

Inibidores da Angiogênese; Neoplasias da Próstata; Animais; Glicólise; Humanos; Concentração de Íons de Hidrogênio; Masculino; Fenótipo; Fator de Necrose Tumoral alfa

Palavras-chave

Acidosis; Anti-VEGF; Buffer therapy; Warburg effect

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Inibidores da Angiogênese Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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