Risk factors associated with severe disease in respiratory syncytial virus infected children under 5 years of age.
Front Pediatr
; 10: 1004739, 2022.
Article
em En
| MEDLINE
| ID: mdl-36110112
ABSTRACT
Objective:
To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection. Studydesign:
We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during three consecutive RSV seasons in 2015-2018. Potential risk factors for severe disease were retrieved through patient questionnaires and linkage to national health registries. Need for respiratory support (invasive ventilation, bi-level positive airway pressure, or continuous positive airway pressure), and length of stay exceeding 72 h were used as measures of disease severity. Associations were investigated using multivariable logistic regression analyses. Multiple imputation was used to avoid bias and inference induced by missing data.Results:
Risk factors associated with a need for respiratory support included age younger than 3 months of age [aOR 6.73 (95% CI 2.71-16.7)], having siblings [aOR 1.65 (95% CI 1.05-2.59)] and comorbidity [aOR 2.40 (95% CI 1.35-4.24)]. The length of hospital stay >72 h was significantly associated with being younger than 3 months of age [aOR 3.52 (95% CI 1.65-7.54)], having siblings [aOR 1.45 (95% CI 1.01-2.08)], and comorbidity [aOR 2.18 (95% CI 1.31-3.61)]. Sub-group analysis of children younger than 6 months of age confirmed the association between both young age and having siblings and the need for respiratory support.Conclusion:
In a large cohort of children <59 months hospitalized with RSV infection, young age, comorbidity, and having siblings were associated with more severe disease.
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MEDLINE
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En
Ano de publicação:
2022
Tipo de documento:
Article