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Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties.
Daniels, Robert; Morato, Erick Orozco; Yassin, Omer A; Mao, Jiahao; Mutlu, Zeynep; Jain, Mayank; Valenti, Joseph; Cakmak, Mukerrem; Nair, Lakshmi S; Sotzing, Gregory A.
Afiliação
  • Daniels R; Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
  • Morato EO; The Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
  • Yassin OA; Department of Skeletal Biology and Regeneration, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
  • Mao J; Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
  • Mutlu Z; School of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.
  • Jain M; School of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.
  • Valenti J; School of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.
  • Cakmak M; College of Agriculture, Health, and Natural Resources, University of Connecticut, Storrs, Connecticut 06269, United States.
  • Nair LS; School of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.
  • Sotzing GA; The Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
ACS Appl Mater Interfaces ; 14(38): 42804-42811, 2022 Sep 28.
Article em En | MEDLINE | ID: mdl-36112124
ABSTRACT
The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high yield for low cost, making it an interesting candidate for polymer feedstock. In this study, two polyesters were synthesized from the condensation of either CBD or cannabigerol (CBG) with adipoyl chloride. Poly(CBD-Adipate) was cast into free-standing films and subjected to thermal, mechanical, and biological characterization. Poly(CBD-Adipate) films exhibited a lack of cytotoxicity toward adipose-derived stem cells while displaying an inherent antioxidant activity compared to poly(lactide) films. Additionally, this material was found to be semi-crystalline and able to be melt-processed into a plastic hemp leaf using a silicone baking mold.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabidiol / Canabinoides / Cannabis Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabidiol / Canabinoides / Cannabis Idioma: En Ano de publicação: 2022 Tipo de documento: Article