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Design and economic investigation of a Multicolumn Countercurrent Solvent Gradient Purification unit for the separation of an industrially relevant PEGylated protein.
Kim, Tae Keun; Sechi, Benedetta; Romero Conde, Juan Jose; Angelo, James; Xu, Xuankuo; Ghose, Sanchayita; Morbidelli, Massimo; Sponchioni, Mattia.
Afiliação
  • Kim TK; Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.
  • Sechi B; Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.
  • Romero Conde JJ; Biologics Process Development, Global Product Development and Supply, Bristol Myers Squibb Inc., Devens, MA 01434, USA.
  • Angelo J; Biologics Process Development, Global Product Development and Supply, Bristol Myers Squibb Inc., Devens, MA 01434, USA.
  • Xu X; Biologics Process Development, Global Product Development and Supply, Bristol Myers Squibb Inc., Devens, MA 01434, USA.
  • Ghose S; Biologics Process Development, Global Product Development and Supply, Bristol Myers Squibb Inc., Devens, MA 01434, USA.
  • Morbidelli M; Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.
  • Sponchioni M; Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy. Electronic address: mattia.sponchioni@polimi.it.
J Chromatogr A ; 1681: 463487, 2022 Oct 11.
Article em En | MEDLINE | ID: mdl-36115185
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Distribuição Contracorrente Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Distribuição Contracorrente Idioma: En Ano de publicação: 2022 Tipo de documento: Article