Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides.
J Am Chem Soc
; 144(38): 17351-17358, 2022 09 28.
Article
em En
| MEDLINE
| ID: mdl-36121772
ABSTRACT
Catalytic branch-selective hydrofunctionalization of feedstock α-olefins to form enantioenriched chiral compounds is a particularly attractive yet challenging transformation in asymmetric catalysis. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of α-olefins through directed C-H cleavage of enamides. This atom-economical addition process is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter. DFT calculations reveal the origin of regio- and enantioselectivity.
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Base de dados:
MEDLINE
Assunto principal:
Alcenos
/
Irídio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article