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Oncogenic ß-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer.
Liu, Fangming; Gai, Xiaochen; Wu, Yuting; Zhang, Baohui; Wu, Xiaoyu; Cheng, Rongrong; Tang, Bufu; Shang, Kezhuo; Zhao, Na; Deng, Weiwei; Chen, Jie; Zhang, Zhengyi; Gu, Song; Zheng, Liang; Zhang, Hongbing.
Afiliação
  • Liu F; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Gai X; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Wu Y; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Zhang B; Department of Physiology, School of Life Science, China Medical University, Shenyang, Liaoning 110122, China.
  • Wu X; Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
  • Cheng R; Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
  • Tang B; Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
  • Shang K; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Zhao N; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Deng W; State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
  • Chen J; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • Zhang Z; Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Gu S; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
  • Zheng L; Department of General Surgery/Surgical Oncology Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
  • Zhang H; Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
Proc Natl Acad Sci U S A ; 119(39): e2202157119, 2022 09 27.
Article em En | MEDLINE | ID: mdl-36122209
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Beta Catenina / Neoplasias Hepáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Beta Catenina / Neoplasias Hepáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article