Assessment of Rotational Thromboelastometry and Thrombin Generation Assay to Identify Risk of High Blood Loss and Re-Operation After Cardiac Surgery.
Clin Appl Thromb Hemost
; 28: 10760296221123310, 2022.
Article
em En
| MEDLINE
| ID: mdl-36124381
ABSTRACT
Introduction:
We aimed to investigate parameters for prediction of post-operative blood loss and re-operation in patients who underwent cardiopulmonary bypass.Methods:
Thrombin generation assay, activated partial thromboplastin time, activated clotting time and rotational thromboelastometry (ROTEM) tests were performed at 4 time points in 65 patients before skin incision (T1), after heparin injection (T2), after protamine reversal (T3) and before skin closure (T4).Results:
Pre-operative endogenous thrombin potential (ETP) and peak thrombin levels were significantly lower in patients with high post-operative blood loss (≥ 800 mL) within 24 h than in those with low blood loss (< 800 mL). Clotting time (CT), maximal clotting firmness, clotting firmness time and alpha angle values of ROTEM measured at T2, T3 or T4 were significant predictors for high post-operative blood loss. An increase in CT-EXTEM over 4 time points was significant in patients who had a re-operation within 48 h compared to their counterparts.Conclusions:
This study indicates that pre-operative ETP could predict high post-operative blood loss and that intra-operative ROTEM also helps to stratify risks of high post-operative blood loss and re-operation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tromboelastografia
/
Procedimentos Cirúrgicos Cardíacos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article