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Detectability of Small Low-Attenuation Lesions With Deep Learning CT Image Reconstruction: A 24-Reader Phantom Study.
Toia, Giuseppe V; Zamora, David A; Singleton, Michael; Liu, Arthur; Tan, Edward; Leng, Shuai; Shuman, William P; Kanal, Kalpana M; Mileto, Achille.
Afiliação
  • Toia GV; Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Mailbox 3252, Madison, WI 53792.
  • Zamora DA; Department of Radiology, University of Washington School of Medicine, Seattle, WA.
  • Singleton M; Institute of Translational Health Sciences, University of Washington, Seattle, WA.
  • Liu A; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA.
  • Tan E; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA.
  • Leng S; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Shuman WP; Department of Radiology, University of Washington School of Medicine, Seattle, WA.
  • Kanal KM; Department of Radiology, University of Washington School of Medicine, Seattle, WA.
  • Mileto A; Department of Radiology, Mayo Clinic, Rochester, MN.
AJR Am J Roentgenol ; 220(2): 283-295, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36129222
ABSTRACT
BACKGROUND. Iterative reconstruction (IR) techniques are susceptible to contrast-dependent spatial resolution, limiting overall radiation dose reduction potential. Deep learning image reconstruction (DLIR) may mitigate this limitation. OBJECTIVE. The purpose of our study was to evaluate low-contrast detectability performance and radiation-saving potential of a DLIR algorithm in comparison with filtered back projection (FBP) and IR using a human multireader noninferiority study design and task-based observer modeling. METHODS. A dual-phantom construct, consisting of a low-contrast detectability module (21 low-contrast hypoattenuating objects in seven sizes [2.4-10.0 mm] and three contrast levels [-15, -10, -5 HU] embedded within liver-equivalent background) and a phantom, was imaged at five radiation exposures (CTDIvol range, 1.4-14.0 mGy; size-specific dose estimate, 2.5-25.0 mGy; 90%-, 70%-, 50%-, and 30%-reduced radiation levels and full radiation level) using an MDCT scanner. Images were reconstructed using FBP, hybrid IR (ASiR-V), and DLIR (TrueFidelity). Twenty-four readers of varying experience levels evaluated images using a two-alternative forced choice. A task-based observer model (detectability index [d']) was calculated. Reader performance was estimated by calculating the AUC using a noninferiority method. RESULTS. Compared with FBP and IR methods at routine radiation levels, DLIR medium and DLIR high settings showed noninferior performance through a 90% radiation reduction (except DLIR medium setting at 70% reduced level). The IR method was non-inferior to routine radiation FBP only for 30% and 50% radiation reductions. No significant difference in d' was observed between routine radiation FBP and DLIR high setting through a 70% radiation reduction. Reader experience was not correlated with diagnostic accuracy (R2 = 0.005). CONCLUSION. Compared with FBP or IR methods at routine radiation levels, certain DLIR algorithm weightings yielded noninferior low-contrast detectability with radiation reductions of up to 90% as measured by 24 human readers and up to 70% as assessed by a task-based observer model. CLINICAL IMPACT. DLIR has substantial potential to preserve contrast-dependent spatial resolution for the detection of hypoattenuating lesions at decreased radiation levels in a phantom model, addressing a major shortcoming of current IR techniques.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aprendizado Profundo Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aprendizado Profundo Idioma: En Ano de publicação: 2023 Tipo de documento: Article