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Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfß-Dependent Mechanisms.
Yu, Haocheng; Sfakianos, John P; Wang, Li; Hu, Yang; Daza, Jorge; Galsky, Matthew D; Sandhu, Harkirat S; Elemento, Olivier; Faltas, Bishoy M; Farkas, Adam M; Bhardwaj, Nina; Zhu, Jun; Mulholland, David J.
Afiliação
  • Yu H; Sema4, Stamford, Connecticut.
  • Sfakianos JP; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Wang L; Sema4, Stamford, Connecticut.
  • Hu Y; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Daza J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
  • Galsky MD; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Sandhu HS; Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Elemento O; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Faltas BM; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
  • Farkas AM; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
  • Bhardwaj N; Departments of Medicine, Cell and Developmental Biology, Weill Cornell Medicine, New York, New York.
  • Zhu J; Parker Institute of Cancer Immunotherapy, San Francisco, California.
  • Mulholland DJ; Parker Institute of Cancer Immunotherapy, San Francisco, California.
Mol Cancer Ther ; 21(11): 1729-1741, 2022 11 03.
Article em En | MEDLINE | ID: mdl-36129800
SIGNIFICANCE: Most patients with bladder cancer do not respond to ICB targeting of the PD-L1 signaling axis. Our modeling applied a de novo resistance signature to show that tumor-infiltrating myeloid cells promote poor treatment response in a TGFß-dependent mechanism.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Antígeno B7-H1 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Antígeno B7-H1 Idioma: En Ano de publicação: 2022 Tipo de documento: Article