The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens).
Sci Adv
; 8(38): eabm4955, 2022 09 23.
Article
em En
| MEDLINE
| ID: mdl-36129976
ABSTRACT
The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo" phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.
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MEDLINE
Assunto principal:
Estudo de Associação Genômica Ampla
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Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article