Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.
Biosci Biotechnol Biochem
; 86(11): 1570-1575, 2022 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-36130217
ABSTRACT
This study reports that black rice bran (BRB) intake for 50-52 consecutive weeks (â¼12 months) reduces tau phosphorylation with a concomitant activation of insulin signaling and subsequent PI3K/AKT pathway in the brain of aged normal mice. BRB holds promise for preventing the formation of neurofibrillary tangles consisting of hyperphosphorylated tau, a pathological hallmark of Alzheimer's disease.
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MEDLINE
Assunto principal:
Oryza
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article