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A new ex-situ machine perfusion device. A preliminary evaluation using a model of donors after circulatory death pig livers.
Ghinolfi, Davide; Melandro, Fabio; Patrono, Damiano; Lai, Quirino; De Carlis, Riccardo; Camagni, Stefania; Gambella, Alessandro; Ruberto, Franco; De Simone, Paolo.
Afiliação
  • Ghinolfi D; Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Melandro F; Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Patrono D; General Surgery 2U-Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
  • Lai Q; Division of General Surgery and Organ Transplantation, Sapienza Università di Roma, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • De Carlis R; Department of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Camagni S; Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Gambella A; Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Ruberto F; Division of General Surgery and Organ Transplantation, Sapienza Università di Roma, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • De Simone P; Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
Artif Organs ; 2022 Jul 04.
Article em En | MEDLINE | ID: mdl-36136037
ABSTRACT
We herein describe a new ex-situ machine perfusion device as a "technology spotlight" using a model of donors after circulatory death liver grafts procured from slaughterhouse pigs. Fourteen pig liver grafts were included. The device allowed stable perfusion in both hypothermic (n = 6) and normothermic (n = 8) conditions and no technical failure was observed. During perfusion, perfusate and bile samples were collected to assess liver metabolism and viability. An integrated adsorption device showed efficient removal of inflammatory cytokines during treatment. This preliminary experience represents the starting point for further investigations on the potential clinical benefits of cytokines and other inflammatory mediators adsorption during machine perfusion.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article