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Assay Sensitivity Difference Can Induce Anti-Hepatitis A Virus IgM Non-Reactive But Total (IgM and IgG) Reactive Results in Early Acute Hepatitis A.
Kim, Soo-Kyung; Yoo, Kwon; Huh, Jungwon.
Afiliação
  • Kim SK; Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
  • Yoo K; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
  • Huh J; Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, Korea. jungwonh@ewha.ac.kr.
J Korean Med Sci ; 37(37): e287, 2022 Sep 26.
Article em En | MEDLINE | ID: mdl-36163480
Although anti-hepatitis A virus (HAV) IgM non-reactive and anti-HAV total (immunoglobulin [Ig] M and IgG) reactive results are generally interpreted as immunity to HAV, some early acute hepatitis A patients show the same results. We compared IgM detection sensitivity between anti-HAV IgM and anti-HAV total assays. Acute hepatitis A patients' samples were serially diluted and tested with Elecsys anti-HAV IgM and total assay (Roche Diagnostics). This resulted in anti-HAV IgM non-reactive but anti-HAV total reactive results. Samples of two hepatitis A patients showing false-negative anti-HAV IgM at initial presentation were analyzed with Elecsys, Atellica (Siemens Healthineers), and Alinity (Abbott Laboratories) HAV assays. Elecsys, Atellica, and Alinity anti-HAV IgM converted reactive on hospital day 3, whereas Elecsys and Atellica anti-HAV total results were reactive from hospital day 1. The anti-HAV total assay had higher sensitivity in detecting IgM antibodies than the anti-HAV IgM assay.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite A Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite A Idioma: En Ano de publicação: 2022 Tipo de documento: Article