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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.
Fink, Elissa A; Xu, Jun; Hübner, Harald; Braz, Joao M; Seemann, Philipp; Avet, Charlotte; Craik, Veronica; Weikert, Dorothee; Schmidt, Maximilian F; Webb, Chase M; Tolmachova, Nataliya A; Moroz, Yurii S; Huang, Xi-Ping; Kalyanaraman, Chakrapani; Gahbauer, Stefan; Chen, Geng; Liu, Zheng; Jacobson, Matthew P; Irwin, John J; Bouvier, Michel; Du, Yang; Shoichet, Brian K; Basbaum, Allan I; Gmeiner, Peter.
Afiliação
  • Fink EA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  • Xu J; Graduate Program in Biophysics, University of California, San Francisco, San Francisco, CA, USA.
  • Hübner H; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
  • Braz JM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Seemann P; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Avet C; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Craik V; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Weikert D; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.
  • Schmidt MF; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Webb CM; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Tolmachova NA; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Moroz YS; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  • Huang XP; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, CA, USA.
  • Kalyanaraman C; Enamine Ltd., 02094 Kyiv, Ukraine.
  • Gahbauer S; Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, 02660 Kyiv, Ukraine.
  • Chen G; National Taras Shevchenko University of Kyiv, 01601 Kyiv, Ukraine.
  • Liu Z; Chemspace, Riga LV-1082, Latvia.
  • Jacobson MP; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Irwin JJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  • Bouvier M; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  • Du Y; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
  • Shoichet BK; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
  • Basbaum AI; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  • Gmeiner P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Science ; 377(6614): eabn7065, 2022 09 30.
Article em En | MEDLINE | ID: mdl-36173843
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Analgésicos não Narcóticos / Descoberta de Drogas / Agonistas de Receptores Adrenérgicos alfa 2 / Manejo da Dor Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Analgésicos não Narcóticos / Descoberta de Drogas / Agonistas de Receptores Adrenérgicos alfa 2 / Manejo da Dor Idioma: En Ano de publicação: 2022 Tipo de documento: Article