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Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review.
Zhang, Shi-Yao; Sun, Xiao-Lei; Yang, Xing-Liang; Shi, Peng-Liang; Xu, Ling-Chuan; Guo, Qing-Mei.
Afiliação
  • Zhang SY; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Sun XL; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Yang XL; School of Classics, Beijing University of Chinese Medicine, Beijing, China.
  • Shi PL; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Xu LC; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Guo QM; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
J Pharm Pharmacol ; 74(11): 1507-1545, 2022 Nov 04.
Article em En | MEDLINE | ID: mdl-36179124
ABSTRACT

OBJECTIVES:

Crataegus pinnatifida (C. pinnatifida), including C. pinnatifida Bge. and its variant C. pinnatifida Bge. var. major N, E. Br., has traditionally been used as a homologous plant for traditional medicine and food in ethnic medical systems in China. Crataegus pinnatifida, especially its fruit, has been used for more than 2000 years to treat indigestion, stagnation of meat, hyperlipidemia, blood stasis, heart tingling, sores, etc. This review aimed to provide a systematic summary on the botany, traditional uses, phytochemistry, pharmacology and clinical applications of C. pinnatifida. KEY

FINDINGS:

This plant contains flavonoids, phenylpropanoids, terpenoids, organic acids, saccharides and essential oils. Experimental studies showed that it has hypolipidemic, antimyocardial, anti-ischemia, antithrombotic, anti-atherosclerotic, anti-inflammatory, antineoplastic neuroprotective activity, etc. Importantly, it has good effects in treating diseases of the digestive system and cardiovascular and cerebrovascular systems.

SUMMARY:

There is convincing evidence from both in vitro and in vivo studies supporting the traditional uses of C. pinnatifida. However, multitarget network pharmacology and molecular docking technology should be used to study the interaction between the active ingredients and targets of C. pinnatifida. Furthermore, exploring the synergy of C. pinnatifida with other Chinese medicines to provide new understanding of complex diseases may be a promising strategy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Botânica / Crataegus Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Botânica / Crataegus Idioma: En Ano de publicação: 2022 Tipo de documento: Article