Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.

Sheehan, Colin T; Hampton, Thomas H; Madden, Dean R

Sheehan, Colin T; Hampton, Thomas H; Madden, Dean R.

Afiliação

Sheehan CT; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Hampton TH; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Madden DR; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. Electronic address: dean.r.madden@dartmouth.edu.

J Biol Chem ; 298(12): 102552, 2022 12.

Article em En | MEDLINE | ID: mdl-36183834

Assuntos

DNA Helicases; Triptofano; DNA Helicases/genética; Mutação; Proteínas de Ligação a Poli-ADP-Ribose/genética; RNA Helicases/genética; Proteínas com Motivo de Reconhecimento de RNA/genética; Triptofano/genética; Humanos

Palavras-chave

bacterial pathogenesis; cancer; crystal structure; crystallography; deubiquitination; intrinsically disordered protein; mutagenesis; mutagenesis in vitro; neurodegeneration; peptide interaction; protein complex; protein structure; proteinprotein interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano / DNA Helicases Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano / DNA Helicases Idioma: En Ano de publicação: 2022 Tipo de documento: Article