Selective histamine H<sub>2</sub> receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice.

Michinaga, Shotaro; Sonoda, Kiyomi; Inazuki, Naoki; Ezaki, Manae; Awane, Hiroki; Shimizu, Kahori; Hishinuma, Shigeru; Mizuguchi, Hiroyuki

Selective histamine H₂ receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice.

Michinaga, Shotaro; Sonoda, Kiyomi; Inazuki, Naoki; Ezaki, Manae; Awane, Hiroki; Shimizu, Kahori; Hishinuma, Shigeru; Mizuguchi, Hiroyuki.

Afiliação

Michinaga S; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. Electronic address: michisho@my-pharm.ac.jp.
Sonoda K; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Inazuki N; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Ezaki M; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Awane H; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Shimizu K; Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.
Hishinuma S; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Mizuguchi H; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan.

J Pharmacol Sci ; 150(3): 135-145, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36184118

Assuntos

Lesões Encefálicas Traumáticas; Agonistas dos Receptores Histamínicos; Angiopoietina-1/metabolismo; Angiopoietina-1/farmacologia; Animais; Barreira Hematoencefálica/metabolismo; Lesões Encefálicas Traumáticas/tratamento farmacológico; Lesões Encefálicas Traumáticas/metabolismo; Dimaprit/metabolismo; Dimaprit/farmacologia; Células Endoteliais/metabolismo; Azul Evans/metabolismo; Azul Evans/farmacologia; Proteínas Hedgehog; Histamina/farmacologia; Agonistas dos Receptores Histamínicos/metabolismo; Agonistas dos Receptores Histamínicos/farmacologia; Masculino; Camundongos; Fatores de Proteção; RNA Mensageiro/metabolismo; Ranitidina/metabolismo; Ranitidina/farmacologia; Receptores Histamínicos H2/genética; Receptores Histamínicos H2/metabolismo; Tiazóis

Palavras-chave

Astrocytes; Blood-brain barrier; Brain microvascular endothelial cells; Histamine H(2) receptor; Traumatic brain injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Agonistas dos Receptores Histamínicos / Lesões Encefálicas Traumáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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