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Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations.
de Almeida, Stéphanie Gomes Santos; Knakcfuss, Fabiana Batalha; Assis, Lívia Maria; de Sousa, Regina Celia Gonçalves; Matuck, Tereza Azevedo; de Carvalho, Deise de Boni Monteiro; Machado, Ricardo Luiz Dantas; Guimarães, Maria Angelica Arpon Marandino; Varella, Rafael Brandão.
Afiliação
  • de Almeida SGS; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Knakcfuss FB; School of Health Sciences, Universidade do Grande Rio, Duque de Caxias, Brazil.
  • Assis LM; Service of Renal Transplantation, Rio de Janeiro State Center of transplantation, São Francisco na Providência de Deus Hospital, Rio de Janeiro, Brazil.
  • de Sousa RCG; Service of Renal Transplantation, Rio de Janeiro State Center of transplantation, São Francisco na Providência de Deus Hospital, Rio de Janeiro, Brazil.
  • Matuck TA; Service of Renal Transplantation, Rio de Janeiro State Center of transplantation, São Francisco na Providência de Deus Hospital, Rio de Janeiro, Brazil.
  • de Carvalho DBM; Service of Renal Transplantation, Rio de Janeiro State Center of transplantation, São Francisco na Providência de Deus Hospital, Rio de Janeiro, Brazil.
  • Machado RLD; Department of Microbiology and Parasitology, Biomedical Institute, Fluminense Federal University, Niterói, Brazil.
  • Guimarães MAAM; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Varella RB; Department of Microbiology and Parasitology, Biomedical Institute, Fluminense Federal University, Niterói, Brazil.
Int J Immunogenet ; 49(6): 379-383, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36193010
We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure (p = .025). This study underscores the role of IFN-γ+874 SNP in CMV infection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Rim / Infecções por Citomegalovirus Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Rim / Infecções por Citomegalovirus Idioma: En Ano de publicação: 2022 Tipo de documento: Article