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Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine-2,4-diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase.
Somandi, Khonzisizwe; Seanego, Tswene D; Dlamini Née Molatsane, Tebogo; Maree, Matthew; de Koning, Charles B; Vanichtanankul, Jarunee; Rattanajak, Roonglawan; Saeyang, Thanaya; Yuthavong, Yongyuth; Kamchonwongpaisan, Sumalee; Rousseau, Amanda L.
Afiliação
  • Somandi K; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
  • Seanego TD; WITS Research Institute for Malaria (WRIM), University of the Witwatersrand, 7 York Road, Johannesburg, Parktown, 2193, South Africa.
  • Dlamini Née Molatsane T; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
  • Maree M; WITS Research Institute for Malaria (WRIM), University of the Witwatersrand, 7 York Road, Johannesburg, Parktown, 2193, South Africa.
  • de Koning CB; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
  • Vanichtanankul J; WITS Research Institute for Malaria (WRIM), University of the Witwatersrand, 7 York Road, Johannesburg, Parktown, 2193, South Africa.
  • Rattanajak R; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
  • Saeyang T; WITS Research Institute for Malaria (WRIM), University of the Witwatersrand, 7 York Road, Johannesburg, Parktown, 2193, South Africa.
  • Yuthavong Y; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
  • Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.
  • Rousseau AL; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.
ChemMedChem ; 17(22): e202200418, 2022 11 18.
Article em En | MEDLINE | ID: mdl-36193872

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas do Ácido Fólico / Antimaláricos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas do Ácido Fólico / Antimaláricos Idioma: En Ano de publicação: 2022 Tipo de documento: Article