Disseminated <i>Mycoplasma Orale</i> Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations.

Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations.

Totten, Arthur H; Uzel, Gulbu; Khil, Pavel P; Youn, Jung-Ho; Treat, Jennifer; Soutar, Craig D; Holland, Steven M; Dekker, John P; Zerbe, Christa S.

Afiliação

Totten AH; Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Uzel G; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Khil PP; Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Youn JH; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Treat J; Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Soutar CD; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Holland SM; Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Dekker JP; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Zerbe CS; Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

Open Forum Infect Dis ; 9(9): ofac472, 2022 Sep.

Article em En | MEDLINE | ID: mdl-36196300

ABSTRACT

Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

Palavras-chave

Mycoplasma orale; PI3KR1; immunodeficiency; phosphoinositide-3-kinase regulatory subunit 1

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article