Fast-tracking antibody maturation using a B cell-based display system.

Masuda, Hitomi; Sawada, Atsushi; Hashimoto, Shu-Ichi; Tamai, Kanako; Lin, Ke-Yi; Harigai, Naoto; Kurosawa, Kohei; Ohta, Kunihiro; Seo, Hidetaka; Itou, Hiroshi

Masuda, Hitomi; Sawada, Atsushi; Hashimoto, Shu-Ichi; Tamai, Kanako; Lin, Ke-Yi; Harigai, Naoto; Kurosawa, Kohei; Ohta, Kunihiro; Seo, Hidetaka; Itou, Hiroshi.

Afiliação

Masuda H; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Sawada A; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Hashimoto SI; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Tamai K; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Lin KY; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Harigai N; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Kurosawa K; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.
Ohta K; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Seo H; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Itou H; Research Laboratories, Chiome Bioscience Inc, Tokyo, Japan.

MAbs ; 14(1): 2122275, 2022.

Article em En | MEDLINE | ID: mdl-36202784

Assuntos

Citidina Desaminase; Hipermutação Somática de Imunoglobulina; Animais; Humanos; Camundongos; Linfócitos B; Citidina Desaminase/genética; Citidina Desaminase/metabolismo; DNA; Imunoglobulina G/genética

Palavras-chave

Affinity maturation; DT40; activation-induced cytidine deaminase; coldspot; deep sequencing; hotspot; somatic hypermutation; therapeutic antibodies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citidina Desaminase / Hipermutação Somática de Imunoglobulina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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