N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA.

Zheng, Xiao; Wang, Qi; Zhou, You; Zhang, Dachuan; Geng, Yiting; Hu, Wenwei; Wu, Changping; Shi, Yufang; Jiang, Jingting

Zheng, Xiao; Wang, Qi; Zhou, You; Zhang, Dachuan; Geng, Yiting; Hu, Wenwei; Wu, Changping; Shi, Yufang; Jiang, Jingting.

Afiliação

Zheng X; Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.
Wang Q; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu, 213003, P. R. China.
Zhou Y; Institute for Cell Therapy of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.
Zhang D; Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.
Geng Y; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu, 213003, P. R. China.
Hu W; Institute for Cell Therapy of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.
Wu C; Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.
Shi Y; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu, 213003, P. R. China.
Jiang J; Institute for Cell Therapy of Soochow University, Changzhou, Jiangsu, 213003, P. R. China.

Cancer Commun (Lond) ; 42(12): 1347-1366, 2022 12.

Article em En | MEDLINE | ID: mdl-36209353

Assuntos

Proteínas Reguladoras de Apoptose; Neoplasias do Colo; Ferroptose; Proteínas Mitocondriais; Acetiltransferases N-Terminal; Humanos; Acetilação; Neoplasias do Colo/genética; Ferroptose/genética; Processos Neoplásicos; RNA Mensageiro/genética; Acetiltransferases N-Terminal/genética; Proteínas Reguladoras de Apoptose/genética; Proteínas Mitocondriais/genética

Palavras-chave

Colon cancer; Ferroptosis; Ferroptosis suppressor protein 1 (FSP1); N-acetyltransferase 10 (NAT10); N4-acetylcytidine (ac4C); RNA acetylation; mRNA stability

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Proteínas Mitocondriais / Proteínas Reguladoras de Apoptose / Acetiltransferases N-Terminal / Ferroptose Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google