Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma.

Mo, Zhuomao; Liu, Daiyuan; Chen, Yihan; Luo, Jin; Li, Wenjing; Liu, Jiahui; Yu, Ling; Huang, Bijun; Zhang, Shijun

Mo, Zhuomao; Liu, Daiyuan; Chen, Yihan; Luo, Jin; Li, Wenjing; Liu, Jiahui; Yu, Ling; Huang, Bijun; Zhang, Shijun.

Afiliação

Mo Z; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong province, China.
Liu D; Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang province, China.
Chen Y; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, Guangdong province, China.
Luo J; Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, 510080, Guangdong province, China.
Li W; Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, Guangdong province, China.
Liu J; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong province, China.
Yu L; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, Guangdong province, China.
Huang B; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong province, China.
Zhang S; Guangdong Province Hospital of Chinese Medicine, AMI Key Laboratory of Chinese Medicine in Guangzhou, Guangzhou, 510120, Guangdong province, China.

J Transl Med ; 20(1): 466, 2022 10 11.

Article em En | MEDLINE | ID: mdl-36221095

Assuntos

Carcinoma Hepatocelular; Epotilonas; Neoplasias Hepáticas; Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patologia; Comunicação Celular; Humanos; Cinesinas; Cirrose Hepática/patologia; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Macrófagos/metabolismo; Linfócitos T; Transcriptoma/genética; Microambiente Tumoral/genética

Palavras-chave

Immunosuppression; Macrophage; Naïve CD4 + T cell; Single cell transcriptomic; Tumor microenvironment

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Epotilonas / Neoplasias Hepáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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