The Autism Spectrum Disorder-Associated Bacterial Metabolite <i>p</i>-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10.

Zheng, Yuanpeng; Prince, Naika Z; Peralta Marzal, Lucia N; Ahmed, Sabbir; Garssen, Johan; Perez Pardo, Paula; Kraneveld, Aletta D

The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10.

Zheng, Yuanpeng; Prince, Naika Z; Peralta Marzal, Lucia N; Ahmed, Sabbir; Garssen, Johan; Perez Pardo, Paula; Kraneveld, Aletta D.

Afiliação

Zheng Y; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Prince NZ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Peralta Marzal LN; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Ahmed S; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Perez Pardo P; Global Centre of Excellence Immunology, Danone-Nutricia Research, 3584 CT Utrecht, The Netherlands.
Kraneveld AD; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.

Int J Mol Sci ; 23(19)2022 Sep 20.

Article em En | MEDLINE | ID: mdl-36232346

Assuntos

Proteínas ADAM; Proteína ADAM17/metabolismo; Transtorno do Espectro Autista; Proteínas ADAM/metabolismo; Proteína ADAM10/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Animais; Transtorno do Espectro Autista/etiologia; Cresóis; Desintegrinas; Glucuronídeos; Interleucina-6/metabolismo; Lipopolissacarídeos/toxicidade; Masculino; Proteínas de Membrana; Camundongos; Microglia/metabolismo; Sulfatos; Ésteres do Ácido Sulfúrico; Fator de Crescimento Transformador beta1; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

ADAM10; ADAM17; autism spectrum disorder; neuroimmune response; p-cresol; p-cresyl sulfate; valproic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ADAM / Transtorno do Espectro Autista / Proteína ADAM17 Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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