Omaveloxolone inhibits IL-1ß-induced chondrocyte apoptosis through the Nrf2/ARE and NF-&#954;B signalling pathways <i>in vitro</i> and attenuates osteoarthritis <i>in vivo</i>.

Jiang, Zengxin; Qi, Guobin; Lu, Wei; Wang, Hao; Li, Defang; Chen, Weibin; Ding, Lei; Yang, Xiuying; Yuan, Hengfeng; Zeng, Qingmin

Omaveloxolone inhibits IL-1ß-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.

Jiang, Zengxin; Qi, Guobin; Lu, Wei; Wang, Hao; Li, Defang; Chen, Weibin; Ding, Lei; Yang, Xiuying; Yuan, Hengfeng; Zeng, Qingmin.

Afiliação

Jiang Z; Department of Orthopaedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
Qi G; Department of Orthopedic Surgery, Fudan University Jinshan Hospital, Shanghai, China.
Lu W; Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Wang H; Department of Orthopedic Surgery, Shanghai TCM-Integrated Hospital Shanghai University of TCM, Shanghai, China.
Li D; Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen W; Department of Orthopedic Surgery, Fudan University Jinshan Hospital, Shanghai, China.
Ding L; Department of Orthopedic Surgery, Fudan University Jinshan Hospital, Shanghai, China.
Yang X; Department of Orthopedic Surgery, Fudan University Jinshan Hospital, Shanghai, China.
Yuan H; Department of Radiology, Fudan University Jinshan Hospital, Shanghai, China.
Zeng Q; Department of Orthopaedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.