Delayed Surgical Closure of the Patent Ductus Arteriosus: Does the Brain Pay the Price?
J Pediatr
; 254: 25-32, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36241053
ABSTRACT
OBJECTIVE:
To investigate the relation between duration of hemodynamically significant patent ductus arteriosus (PDA), cerebral oxygenation, magnetic resonance imaging-determined brain growth, and 2-year neurodevelopmental outcome in a cohort of infants born preterm whose duct was closed surgically. STUDYDESIGN:
Infants born preterm at <30 weeks of gestational age who underwent surgical ductal closure between 2008 and 2018 (n = 106) were included in this observational study. Near infrared spectroscopy-monitored cerebral oxygen saturation during and up to 24 hours after ductal closure and a Bayley III developmental test at the corrected age of 2 years is the institutional standard of care for this patient group. Infants also had magnetic resonance imaging at term-equivalent age.RESULTS:
In total, 90 infants fulfilled the inclusion criteria (median [range] 25.9 weeks [24.0-28.9]; 856 g [540-1350]. Days of a PDA ranged from 1 to 41. Multivariable linear regression analysis showed that duration of a PDA negatively influenced cerebellar growth and motor and cognitive outcome at 2 years of corrected age.CONCLUSIONS:
Prolonged duration of a PDA in this surgical cohort is associated with reduced cerebellar growth and suboptimal neurodevelopmental outcome.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade do Canal Arterial
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article