Structure and antiproliferative activity of the polysaccharide from Halomonas aquamarina related to Cobetia pacifica.
Carbohydr Polym
; 298: 120125, 2022 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-36241297
ABSTRACT
Here, the results of the structure and the activity of capsular polysaccharides isolated from the Halomonas aquamarina EG27S8QL and Cobetia pacifica KMM3878 have been described. Both polysaccharides were studied by spectroscopic and chemical methods and were found to be structurally related sulfated galactans differing in the position of the sulfate group â6)-ß-D-Galp3S-(1 â 4)-ß-D-Galp3S-(1 â 6)-ß-D-Galp3,4(S-Pyr)-(1 â [H. aquamarina EG27S8QL] â6)-ß-D-Gal-(1 â 4)-ß-D-Gal2,3S-(1 â 6)-ß-D-Gal3,4(S-Pyr)-(1 â [C. pacifica KMM3878] Structure of the CPS from H. aquamarina EG27S8QL has not been hitherto reported, whereas the CPS from C. pacifica KMM3878 was identical to the previously studied O-polysaccharide. The CPSs exhibited an antiproliferative effect and suppressed the colony formation of DLD-1 and MCF-7 cells in a different manner.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Sulfatos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article