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Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Narayanan, Dilip; Tran, Kim T; Pallesen, Jakob S; Solbak, Sara M Ø; Qin, Yuting; Mukminova, Elina; Luchini, Martina; Vasilyeva, Kristina O; González Chichón, Dorleta; Goutsiou, Georgia; Poulsen, Cecilie; Haapanen, Nanna; Popowicz, Grzegorz M; Sattler, Michael; Olagnier, David; Gajhede, Michael; Bach, Anders.
Afiliação
  • Narayanan D; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Tran KT; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Pallesen JS; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Solbak SMØ; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Qin Y; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Mukminova E; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Luchini M; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Vasilyeva KO; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • González Chichón D; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Goutsiou G; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Poulsen C; Department of Biomedicine, Faculty of Health, Aarhus University, 8000 Aarhus C, Denmark.
  • Haapanen N; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Popowicz GM; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
  • Sattler M; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, 85747 Garching, Germany.
  • Olagnier D; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
  • Gajhede M; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, 85747 Garching, Germany.
  • Bach A; Department of Biomedicine, Faculty of Health, Aarhus University, 8000 Aarhus C, Denmark.
J Med Chem ; 65(21): 14481-14526, 2022 11 10.
Article em En | MEDLINE | ID: mdl-36263945
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Descoberta de Drogas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Descoberta de Drogas Idioma: En Ano de publicação: 2022 Tipo de documento: Article