Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis.

Kelly, Jenna N; Laloli, Laura; V'kovski, Philip; Holwerda, Melle; Portmann, Jasmine; Thiel, Volker; Dijkman, Ronald

Kelly, Jenna N; Laloli, Laura; V'kovski, Philip; Holwerda, Melle; Portmann, Jasmine; Thiel, Volker; Dijkman, Ronald.

Afiliação

Kelly JN; Institute of Virology and Immunology, Bern, Switzerland.
Laloli L; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
V'kovski P; Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland.
Holwerda M; Institute of Virology and Immunology, Bern, Switzerland.
Portmann J; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Thiel V; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Dijkman R; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.

Front Immunol ; 13: 978824, 2022.

Article em En | MEDLINE | ID: mdl-36268025

Assuntos

Vírus da Influenza A; Influenza Humana; Humanos; Análise de Célula Única; Pandemias; Interferons/genética; Interferons/metabolismo; Citocinas; Antivirais; Progressão da Doença

Palavras-chave

human airway epithelium; influenza viruses; innate immunity; single cell analysis; virus-host interactions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Influenza Humana Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Influenza Humana Idioma: En Ano de publicação: 2022 Tipo de documento: Article