Separation of closely related monoclonal antibody charge variant impurities using poly(ethylenimine)-grafted cation-exchange chromatography resin.

Sivanathan, Ganesh T; Mallubhotla, Hanuman; Suggala, Satyanarayana V; Tholu, Manikanta Sriharsha

Sivanathan, Ganesh T; Mallubhotla, Hanuman; Suggala, Satyanarayana V; Tholu, Manikanta Sriharsha.

Afiliação

Sivanathan GT; Department of Chemical Engineering, JNTUA, Ananthapuramu, Andhra Pradesh 515002 India.
Mallubhotla H; Biopharmaceutical Development, Syngene International Ltd., Bangalore, 560099 India.
Suggala SV; Biopharmaceutical Development, Syngene International Ltd., Bangalore, 560099 India.
Tholu MS; Department of Chemical Engineering, JNTUA, Ananthapuramu, Andhra Pradesh 515002 India.

3 Biotech ; 12(11): 293, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36276450

Palavras-chave

Cation-exchange chromatography; Charge variants; LGE model; Linear gradient elution; Multi modal chromatography; Poly ABX; Poly CSX; Single-chain variable antibody fragment; Thermodynamic model; scFv−Fc−Ab

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article