Combining Enzyme and Photoredox Catalysis for the Construction of 3-Aminoalkyl Chromones.
J Org Chem
; 87(21): 14965-14969, 2022 11 04.
Article
em En
| MEDLINE
| ID: mdl-36279475
ABSTRACT
Herein, we reported a practical and efficient strategy combining photoredox and enzyme catalysis for the construction of 3-aminoalkyl chromones from o-hydroxyaryl enaminones and N-arylglycine esters. A variety of 3-aminoalkyl chromones were synthesized with good yields under mild conditions in one pot. This synthetic protocol consists of sequential enzymatic hydrolysis and photoredox decarboxylation of N-arylglycine esters, oxidation of aminoalkyl radicals, Mannich reaction, and intramolecular nucleophilic cyclization, which affords a convenient pathway for the preparation of various 3-substituted chromones.
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En
Ano de publicação:
2022
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Article