Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis.

Schuler, Cordelia; Foti, Federica; Perren, Leonie; Mamie, Céline; Weder, Bruce; Stokmaier, Michelle; de Vallière, Cheryl; Heuchel, Rainer; Ruiz, Pedro A; Rogler, Gerhard; Hausmann, Martin

Schuler, Cordelia; Foti, Federica; Perren, Leonie; Mamie, Céline; Weder, Bruce; Stokmaier, Michelle; de Vallière, Cheryl; Heuchel, Rainer; Ruiz, Pedro A; Rogler, Gerhard; Hausmann, Martin.

Afiliação

Schuler C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Foti F; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Perren L; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Mamie C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Weder B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Stokmaier M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
de Vallière C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Heuchel R; Pancreas Cancer Research Lab, CLINTEC, Karolinska Institutet, Huddinge, Sweden.
Ruiz PA; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Rogler G; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Hausmann M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Inflamm Bowel Dis ; 29(4): 647-660, 2023 04 03.

Article em En | MEDLINE | ID: mdl-36282601

We evaluated the effect of Smad7 deficiency on inflammation and fibrogenesis. Smad7 deficiency was associated with ameliorated inflammation and increased collagen deposition. When targeting Smad7 as therapeutic strategy in IBD, potential initiation or aggravation of fibrosis should be considered.

Assuntos

Colite; Dextranos; Animais; Camundongos; Colite/induzido quimicamente; Colite/genética; Colite/metabolismo; Colágeno/metabolismo; Dextranos/metabolismo; Fibrose; Inflamação/metabolismo; Camundongos Endogâmicos C57BL; RNA Mensageiro; Proteína Smad7/genética; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

fibrosis; inflammatory bowel disease; mongersen

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dextranos / Colite Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dextranos / Colite Idioma: En Ano de publicação: 2023 Tipo de documento: Article