A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection.
Rev Soc Bras Med Trop
; 55: e02392022, 2022.
Article
em En
| MEDLINE
| ID: mdl-36287506
ABSTRACT
BACKGROUND:
The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19).METHODS:
We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC).RESULTS:
The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis.CONCLUSIONS:
SC, as well as AS was characterized by an inflammatory profile.
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Base de dados:
MEDLINE
Assunto principal:
COVID-19
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article