Discovery of a Dual SENP1 and SENP2 Inhibitor.

Brand, Michael; Bommeli, Elias Benjamin; Rütimann, Marc; Lindenmann, Urs; Riedl, Rainer

Brand, Michael; Bommeli, Elias Benjamin; Rütimann, Marc; Lindenmann, Urs; Riedl, Rainer.

Afiliação

Brand M; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Bommeli EB; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Rütimann M; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Lindenmann U; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Riedl R; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.

Int J Mol Sci ; 23(20)2022 Oct 11.

Article em En | MEDLINE | ID: mdl-36292935

Assuntos

Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina; Sumoilação; Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina/metabolismo; Piruvatos; Endopeptidases/metabolismo; Peptídeo Hidrolases/metabolismo

Palavras-chave

SENP; cancer; deubiquitinating enzymes; drug discovery; inhibitors; medicinal chemistry; small molecules; structure activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina / Sumoilação Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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