Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B.

Garrison, Dominique A; Jin, Yan; Talebi, Zahra; Hu, Shuiying; Sparreboom, Alex; Baker, Sharyn D; Eisenmann, Eric D

Garrison, Dominique A; Jin, Yan; Talebi, Zahra; Hu, Shuiying; Sparreboom, Alex; Baker, Sharyn D; Eisenmann, Eric D.

Afiliação

Garrison DA; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Jin Y; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Talebi Z; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Hu S; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Sparreboom A; Division of Outcomes and Translational Sciences, The Ohio State University, Columbus, OH 43210, USA.
Baker SD; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Eisenmann ED; Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.

Molecules ; 27(20)2022 Oct 12.

Article em En | MEDLINE | ID: mdl-36296409

Assuntos

Itraconazol; Leucemia Mieloide Aguda; Camundongos; Animais; Itraconazol/farmacologia; Citocromo P-450 CYP3A/genética; Inibidores do Citocromo P-450 CYP3A/farmacologia; Compostos de Anilina/farmacologia; Leucemia Mieloide Aguda/tratamento farmacológico; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

CYP3A; OATP1B; drugdrug interactions; gilteritinib; itraconazole; pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Itraconazol Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Itraconazol Idioma: En Ano de publicação: 2022 Tipo de documento: Article