AKBA inhibits radiotherapy resistance in lung cancer by inhibiting maspin methylation and regulating the AKT/FOXO1/p21 axis.

Gong, Chun; Li, Wei; Wu, Jing; Li, Yao-Yao; Ma, Yi; Tang, Li-Wen

Gong, Chun; Li, Wei; Wu, Jing; Li, Yao-Yao; Ma, Yi; Tang, Li-Wen.

Afiliação

Gong C; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.
Li W; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.
Wu J; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.
Li YY; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.
Ma Y; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.
Tang LW; Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.

J Radiat Res ; 64(1): 33-43, 2023 Jan 20.

Article em En | MEDLINE | ID: mdl-36300343

Assuntos

Neoplasias Pulmonares; Proteínas Proto-Oncogênicas c-akt; Triterpenos; Humanos; Apoptose; Linhagem Celular Tumoral; Proliferação de Células; Proteína Forkhead Box O1/metabolismo; Proteína Forkhead Box O1/farmacologia; Neoplasias Pulmonares/radioterapia; Metilação; Proteínas Proto-Oncogênicas c-akt/metabolismo; Triterpenos/farmacologia

Palavras-chave

AKT/FOXO1/p21 axis; acetyl-keto-b-boswellic acid (AKBA); lung cancer; maspin; radioresistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Proteínas Proto-Oncogênicas c-akt / Neoplasias Pulmonares Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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