HDAC4 depletion ameliorates IL-13-triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF-&#954;B signaling.

Xu, Hangyu; Wang, Lingjun; Chen, Huaqun; Cai, Hefei

HDAC4 depletion ameliorates IL-13-triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF-κB signaling.

Xu, Hangyu; Wang, Lingjun; Chen, Huaqun; Cai, Hefei.

Afiliação

Xu H; Department of Otolaryngology, Taizhou Central Hospital, Taizhou University Hospital, Taizhou, Zhejiang, China.
Wang L; Department of General Practice, Taizhou Central Hospital, Taizhou University Hospital, Taizhou, Zhejiang, China.
Chen H; Department of Geriatrics, Taizhou Central Hospital, Taizhou University Hospital, Taizhou, Zhejiang, China.
Cai H; Department of Pediatrics, Taizhou Central Hospital, Taizhou University Hospital, Taizhou, Zhejiang, China.

Immun Inflamm Dis ; 10(11): e692, 2022 11.

Article em En | MEDLINE | ID: mdl-36301023

Assuntos

NF-kappa B; Rinite Alérgica; Humanos; NF-kappa B/metabolismo; Sirtuína 1/genética; Sirtuína 1/metabolismo; Interleucina-13/metabolismo; Histamina/farmacologia; Mucosa Nasal/metabolismo; Células Epiteliais/metabolismo; Imunoglobulina E/metabolismo; Muco/metabolismo; Histona Desacetilases/genética; Histona Desacetilases/metabolismo; Proteínas Repressoras/metabolismo

Palavras-chave

HDAC4; MUC5AC; SIRT1/NF-κB signaling; allergic rhinitis; inflammatory response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Rinite Alérgica Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Rinite Alérgica Idioma: En Ano de publicação: 2022 Tipo de documento: Article