Catalytic divergent synthesis of imidazoles via reaction condition-dependent [3 + 2] cyclization of TosMIC.
Org Biomol Chem
; 20(44): 8623-8627, 2022 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-36314887
ABSTRACT
A base-catalyzed divergent synthesis of multisubstituted imidazoles through TosMIC-based [3 + 2] cyclization reaction has been developed. In the presence of ketenimines and tBuONa, 1,4,5-trisubstituted imidazoles were obtained. Nonetheless, in the absence of ketenimines, 1,4-disubstituted imidazole was produced through cyclodimerization of TosMIC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cianetos
/
Imidazóis
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article