Non-coding RNA and their potential role in cardiovascular diseases.

ABSTRACT

BACKGROUND: Cardiovascular diseases are the leading cause of mortality worldwide. The timely diagnosis of CVD is still an unmet challenge. Non-coding RNAs which were earlier considered to be "junk DNA" are now considered to play crucial role as potential transcriptional regulators and therapeutic targets for treatment of CVDs. METHODOLOGY: A literature search has been performed on PubMed, SCOPUS where keywords such as "non- coding RNAs" and "coronary artery disease" and "miRNAs" and "Myocardial infarction" or "cardiovascular diseases" were used with no date restriction in writing this review article. CONCLUSION: This review focus on the role of non- coding RNAs in cardiovascular disease along with the database which can enhance the efficiency of experimental analysis of non-coding RNAs.