Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.

Jefferson, Tanner B; Wang, Tianyuan; Jefferson, Wendy N; Li, Yin; Hamilton, Katherine J; Wade, Paul A; Williams, Carmen J; Korach, Kenneth S

Jefferson, Tanner B; Wang, Tianyuan; Jefferson, Wendy N; Li, Yin; Hamilton, Katherine J; Wade, Paul A; Williams, Carmen J; Korach, Kenneth S.

Afiliação

Jefferson TB; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Wang T; Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Jefferson WN; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Li Y; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Hamilton KJ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Wade PA; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Williams CJ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
Korach KS; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.

Epigenetics ; 18(1): 2139986, 2023 12.

Article em En | MEDLINE | ID: mdl-36328762

Assuntos

Dietilestilbestrol; Receptor alfa de Estrogênio; Animais; Camundongos; Masculino; Feminino; Dietilestilbestrol/farmacologia; Receptor alfa de Estrogênio/genética; Metilação de DNA; Estudo de Associação Genômica Ampla; Epigênese Genética; Expressão Gênica

Palavras-chave

Estrogen receptor; histone modification; mouse seminal vesicles; neonatal DES exposure; transcriptome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor alfa de Estrogênio / Dietilestilbestrol Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor alfa de Estrogênio / Dietilestilbestrol Idioma: En Ano de publicação: 2023 Tipo de documento: Article