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Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system.
Horta, Erika; Burke-Smith, Conor; Megna, Bryant W; Nichols, Kendall J; Vaughn, Byron P; Reshi, Rwoof; Shmidt, Eugenia.
Afiliação
  • Horta E; Department of Neurology, University of Arkansas Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA.
  • Burke-Smith C; University of Iowa Carver College of Medicine, 375 Newton Rd, Iowa City, IA, 52242, USA.
  • Megna BW; Inflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of Minnesota, 516 Delaware St Se, Minneapolis, MN, 55455, USA. Megna003@umn.edu.
  • Nichols KJ; Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, 420 Delaware Street SE, MMC 36, Minneapolis, MN, 55455, USA. Megna003@umn.edu.
  • Vaughn BP; Department of Neurology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN, 55455, USA.
  • Reshi R; Inflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of Minnesota, 516 Delaware St Se, Minneapolis, MN, 55455, USA.
  • Shmidt E; The University of Oklahoma Health Sciences Center, 865 Research Pkwy, Oklahoma City, OK, 73104, USA.
Sci Rep ; 12(1): 18668, 2022 11 04.
Article em En | MEDLINE | ID: mdl-36333367
ABSTRACT
In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic distribution, and risk factors for CVA in patients with UC. We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered. Prevalence of CVAs in patients with UC was compared to that of the general population of Minnesota (MN) and the United States (U.S.). A total of 2,183 UC patients were identified (1088 females [f-UC], 1095 males [m-UC]). The prevalence of CVA in UC patients (4.7%, 95% CI 3.9-5.6) was higher than in the U.S. (2.5-2.7%, p < 0.0001) and in Minnesota (1.8% CI 1.5-2.2, p < 0.0001) . The prevalence increased in both sexes with a peak prevalence of 24.7% (95% CI 17.1-34.4) in women with UC over the age of 80. Older age, cancer and atrial fibrillation were risk factors for CVA in univariate analysis for both sexes. In multifactorial analysis, both age and atrial fibrillation were risk factors for CVA in the m-UC cohort, but only age was associated with CVA in f-UC. The most common type of CVA was ischemic stroke (77.7%). The most common locations for CVAs in UC patients were frontal and occipital lobes (19% and 18%, respectively). UC patients have an increased risk for CVA, with women over 80 demonstrating the highest risk. Providers should be aware of these risks in making treatment decisions for UC.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Colite Ulcerativa / Acidente Vascular Cerebral Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Colite Ulcerativa / Acidente Vascular Cerebral Idioma: En Ano de publicação: 2022 Tipo de documento: Article