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The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead.
Nguyen, Kim-Anh; Conilh, Louise; Falson, Pierre; Dumontet, Charles; Boumendjel, Ahcène.
Afiliação
  • Nguyen KA; University of Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
  • Conilh L; Cancer Research Center of Lyon (CRCL), INSERM, 1052/CNRS, 5286/UCBL, 69000, Lyon, France.
  • Falson P; Drug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, Passage du Vercors, 69367, Lyon, France.
  • Dumontet C; Cancer Research Center of Lyon (CRCL), INSERM, 1052/CNRS, 5286/UCBL, 69000, Lyon, France; Hospices Civils de Lyon, 69000, Lyon, France.
  • Boumendjel A; University of Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France. Electronic address: ahcene.boumendjel@univ-grenoble-alpes.fr.
Eur J Med Chem ; 244: 114863, 2022 Dec 15.
Article em En | MEDLINE | ID: mdl-36334452
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Ferroptose Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Ferroptose Idioma: En Ano de publicação: 2022 Tipo de documento: Article