Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases.

Tanji, Yoshiaki; Furukawa, Kenei; Haruki, Koichiro; Taniai, Tomohiko; Onda, Shinji; Tsunematsu, Masashi; Shirai, Yoshihiro; Yanagaki, Mitsuru; Igarashi, Yosuke; Ikegami, Toru

Tanji, Yoshiaki; Furukawa, Kenei; Haruki, Koichiro; Taniai, Tomohiko; Onda, Shinji; Tsunematsu, Masashi; Shirai, Yoshihiro; Yanagaki, Mitsuru; Igarashi, Yosuke; Ikegami, Toru.

Afiliação

Tanji Y; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Furukawa K; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Haruki K; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Taniai T; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Onda S; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Tsunematsu M; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Shirai Y; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Yanagaki M; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Igarashi Y; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.
Ikegami T; Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan.

Ann Gastroenterol Surg ; 6(6): 804-812, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36338593

ABSTRACT

ABSTRACT

Introduction:

The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long-term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection.

Method:

In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long-term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil-lymphocyte ratio.

Results:

The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48-5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20-0.98, P = .04) were independent and significant predictors of disease-free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03-5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05-0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23-8.78, P = .02) were independent and significant predictors of overall survival.