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Collective Total Syntheses of Benzo[c]phenanthridine Alkaloids via a Sequential Transition Metal-Catalyzed Pot-Economic Approach.
Fu, Jiayue; Li, Bingbing; Wang, Xinxiu; Wang, He; Deng, Minghui; Yang, Huali; Lin, Bin; Cheng, Maosheng; Yang, Lu; Liu, Yongxiang.
Afiliação
  • Fu J; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
  • Li B; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Wang X; Institute of Drug Research in Medicine Capital of China, Benxi 117000, P. R. China.
  • Wang H; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
  • Deng M; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Yang H; Institute of Drug Research in Medicine Capital of China, Benxi 117000, P. R. China.
  • Lin B; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
  • Cheng M; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Yang L; Institute of Drug Research in Medicine Capital of China, Benxi 117000, P. R. China.
  • Liu Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
Org Lett ; 24(45): 8310-8315, 2022 11 18.
Article em En | MEDLINE | ID: mdl-36342358
ABSTRACT
Collective total syntheses of 10 benzo[c]phenanthridines were achieved on the basis of the construction of rings C and B through sequential transition metal-catalyzed reactions and flexible condition-controlled Mannich reaction via three pots in 25-34% yields, which provided an efficient route to benzo[c]phenanthridines via a pot-economic approach.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos de Transição / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos de Transição / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article